US-Based Startups
AIMM — Advanced & Innovative Multifunctional Materials
FOUNDER
INDUSTRY/SECTOR
Sustainability & Circular Materials
HQ
Dayton, Ohio
WEBSITE
AIMM develops tunable hierarchically porous carbon (HPC) materials for industrial wastewater treatment. HPCs are a porous charcoal and thus a direct drop-in replacement for conventional activated carbon (AC) systems. However, HPC’s tunable nature (porosity, surface chemistry, etc.) enables them to remove up to 200X more contaminants, such as dyes, at ultrafast sorption speeds of 5-15 seconds, rather than hours for AC. Their tunability also broadens their ability to treat various PFAS, including short-chain PFAS which AC struggles with. The company is commercializing technology developed at the University of Dayton and is currently focused on pilot-scale deployment.
Clear Skies Hydrogen / CSH2 Corp
FOUNDER
INDUSTRY/SECTOR
Hydrogen & Fuel Cells
HQ
Princeton, New Jersey
WEBSITE
Clear Skies Hydrogen / CSH2 Corp is building modular hydrogen refueling infrastructure for medium- and heavy-duty fuel-cell vehicles, using cryopump-based, containerized station systems designed to reduce fueling cost, boil-off losses, CapEx and deployment time.
Concerto Biosciences
FOUNDER
INDUSTRY/SECTOR
Biotech & Life Science
HQ
Cambridge, Massachusetts
WEBSITE
Concerto Biosciences is a biotechnology company using its kChip high-throughput microbial screening platform and kAI model to design microbe-based therapeutics and products across skin health, women’s health and food science. Its lead program, ENS-002, is a live biotherapeutic for atopic dermatitis, and its known commercial partner includes Sacco System for next-generation microbial ingredient discovery.
CPTI / California Perovskite Technology Inc.
FOUNDER
INDUSTRY/SECTOR
Advanced Materials & Efficiency
HQ
San Francisco, California
WEBSITE
CPTI builds ultra-thin, flexible perovskite photovoltaic systems that turn any surface into a power source – for IoT sensors, wearables, robotics, devices, and buildings. We offer standard panels for customer evaluation today and can co-design custom dimensions and output voltages for specific form factors.
Deep Anchor Solutions
FOUNDER
INDUSTRY/SECTOR
Advanced Materials & Efficiency
HQ
Houston, Texas
Deep Anchor Solutions develops scalable, cost-effective anchoring systems for floating offshore infrastructure. Its flagship technology, the Deeply Embedded Ring Anchor (DERA), uses a compact, steel pipe-based architecture designed to reduce fabrication, transportation, and installation costs. The company also provides project-specific engineering services to support offshore deployment.
HidrogeniCs
FOUNDER
INDUSTRY/SECTOR
Hydrogen & Fuel Cells
HQ
Lemont, Illinois
WEBSITE
Hidrogenics is an Advanced Materials and Energy startup building high-value carbon products (e.g., synthetic graphite (a critical material), graphene, carbon nanotubes, and carbon black) for commercial and defense applications. Our target partners include battery manufacturers, the electronic & semiconductor sectors, prime contractors (aviation & space), and the oil and gas industries.
Kenyi Technologies
FOUNDER
INDUSTRY/SECTOR
Semiconductor
HQ
Newark, New Jersey
WEBSITE
Kenyi Technologies is building a next-generation edge infrastructure platform for telecom, cloud-native edge computing and AI inferencing. Founded by ex-Qualcomm engineers, the company uses chiplet technology to combine an ARM server-grade CPU with Kenyi’s Edge Server DPU acceleration, targeting use cases such as vRAN, 5G/6G edge networks, video analytics and proximal AI inferencing. Kenyi has announced a strategic partnership with ADTechnology to co-develop a 2nm edge server processor.
Lift Biolabs
FOUNDER
INDUSTRY/SECTOR
Biotech & Life Science
HQ
Houston, Texas
Lift Biolabs is a biomanufacturing tools company developing affinity purification products designed to make biologics easier and less expensive to produce. Our tools are genetically encodable protein-shell nanobubbles produced by fermentation. They capture high-value biologics and separate them in bulk by flotation. Lift Biolabs is starting with viral vector purification and developing separation products for emerging biologics that are difficult to purify using existing technologies.
Manifest Technologies
FOUNDER
INDUSTRY/SECTOR
Advanced Manufacturing & Additive Manufacturing
HQ
Boulder, Colorado
WEBSITE
Manifest Technologies is an advanced manufacturing company enabling the production of smart lenses and other complex, high-value products. Its patented Parallax Volumetric Additive Manufacturing, or P-VAM, platform uniquely helps manufacturers overcome the slow, expensive assembly steps required by traditional production methods, enabling faster manufacturing, greater design freedom, and a path to thinner, fully integrated next-generation devices. Manifest is commercializing technology developed at the University of Colorado Boulder, with an initial focus on optics and future applications across other advanced industrial sectors.
Prolific Machines
FOUNDER
INDUSTRY/SECTOR
Biotech & Life Science
HQ
Emeryville, California
Prolific Machines is a biotechnology company developing a Photomolecularâ„¢ biomanufacturing platform that uses light, optogenetics and AI-driven process optimization to control cell behavior and improve production of biotherapeutics, antibodies, biosimilars and other biologics. The company works with biotech, pharmaceutical and CDMO partners.
Sepion Technologies
FOUNDER
INDUSTRY/SECTOR
Battery and Storage
HQ
Emeryville, California
WEBSITE
Sepion Technologies develops advanced polymer coatings and membrane technologies for next-generation battery separators, helping improve battery safety, fast-charging performance, energy density and cost without requiring major changes to existing lithium-ion manufacturing lines. Its products are used across EV, energy storage and consumer electronics applications, with customer qualification programs underway with global battery manufacturers and a partnership with Shenzhen Senior Technology Material.
SHARP Diagnostics
FOUNDER
INDUSTRY/SECTOR
Biotech & Life Science
HQ
Baltimore, Maryland
WEBSITE
SHARP Diagnostics is a Johns Hopkins–born biotechnology startup developing rapid, portable and scalable nucleic-acid detection technology using isothermal amplification. Its SHARP platform uses engineered helicase molecular motors to amplify DNA/RNA at a constant temperature, eliminating the need for a thermocycler while aiming to preserve PCR-like sensitivity, specificity and workflow compatibility. The company sells a research-use-only SHARP Isothermal DNA Amplification Kit and is targeting applications across point-of-care molecular diagnostics, infectious disease testing, HIV, HCV, TB, COVID-19, influenza, agricultural diagnostics and biothreat detection. Known early customers/users include research customers in Switzerland, Belgium, Germany, New York, California and Maryland.
Sustainable Chemicals
FOUNDER
INDUSTRY/SECTOR
Sustainability & Circular Materials
HQ
Arvada, Colorado
WEBSITE
Sustainable Chemicals, Inc. is a startup developing patent-protected, AI-enabled, plant-based bioplastics that match petrochemical plastics in cost and performance, reduce COâ‚‚ emissions by 45%, fully biodegrade in soil without persistent microplastics, and enable low-temperature chemical recycling.
Our shared chemistry platform includes Flexoxaâ„¢, a biobased plasticizer targeting the $17 billion biobased additives market, and Reploseâ„¢, a low-modulus bioplastic targeting the $90 billion flexible films market. Our non-fermentation process uses commercially available equipment and is designed for petrochemical-comparable cost and scalability.
Tyfast Energy Corp.
FOUNDER
INDUSTRY/SECTOR
Battery and Storage
HQ
San Diego, California
WEBSITE
Tyfast Energy is developing lithium vanadium oxide anode materials for fast-charging, long-life lithium-ion batteries targeting heavy-duty applications including trucking, mining, construction and defense. Known partners and strategic collaborators include GUS Technology, US Vanadium, Strategic Resources, Bradda Head Lithium, NSF, DOE/ARPA-E, U.S. Army, U.S. Air Force, California Energy Commission, CalSEED and Activate/Cyclotron Road.
Vellex Computing
FOUNDER
INDUSTRY/SECTOR
Semiconductor
HQ
San Francisco, California
WEBSITE
Vellex Computing is a Stanford spin-out analog semiconductor company developing ultra-low-power chips for AI training. Powered by a decade of research and backed by the U.S. National Science Foundation and Department of Energy, Vellex’s technology delivers AI training at a fraction of the energy cost of GPU-based solutions. The company holds multiple patents and has active pilots across energy, data center, and edge AI applications. Vellex is raising $1.25M in a pre-seed round to cross the commercial threshold and accelerate commercialization, and is looking to partner with OEMs and chipmakers.














