US-Based Startups
AeroShield Materials
FOUNDER
INDUSTRY/SECTOR
Building Materials & Energy Efficiency
HQ
Waltham, Massachusetts
WEBSITE
AeroShield Materials is an MIT spinout that manufactures the world’s most insulating, lightest, transparent materials. AeroShield enables the next generation of high-performance and energy-efficient products across windows, freezers, automotive, aerospace, and more.
Brightlight Photonics
FOUNDER
INDUSTRY/SECTOR
Photonics & Quantum
HQ
Cambridge, Massachusetts
Brightlight Photonics develops on-chip lasers and amplifiers made from titanium-doped thin-film sapphire and custom photonic solutions in the visible and ultraviolet, from bare chips to fiber-interfaced devices.
CavilinQ
FOUNDER
INDUSTRY/SECTOR
Quantum Hardware
HQ
Cambridge, Massachusetts
WEBSITE
CavilinQ provides the most economical, clean, and continuous path to next-generation fault-tolerant quantum computers and quantum data centers.
ESTAT Actuation
FOUNDER
INDUSTRY/SECTOR
Robotics & Actuation
HQ
Pittsburgh, Pennsylvania
WEBSITE
ESTAT Actuation builds ESTAT clutches are 10x lighter, 10x more compact, and 1000x more efficient than conventional clutches. ESTAT clutches use electroadhesion to “glue” and “unglue” surfaces, enabling new actuator designs for mobile robots, logistics robots, wearable robots and manufacturing systems.
FlowCellutions
FOUNDER
INDUSTRY/SECTOR
Grid Storage & Battery Diagnostics
HQ
Houston, Texas
WEBSITE
FlowCellutions builds state-of-health diagnostics, proprietary sensing, and predictive maintenance software for grid-scale/flow batteries to extend battery life, prevent critical-infrastructure outages, and reduce O&M/OPEX for battery manufacturers, data centers, hospitals, and grid operators.
Gallox Semiconductors
FOUNDER
INDUSTRY/SECTOR
Semiconductors & Photonics
HQ
Ithaca, New York
WEBSITE
Gallox Semiconductors develops ultrawide bandgap gallium oxide (Ga2O3) transistors and diodes that eliminate that inefficiency, enable more powerful electronics circuitry, and reduce a system’s size, weight, and engineering complexity with target applications including data center, EV charging, satellites, drones, and aircraft.
Helix Earth
FOUNDER
INDUSTRY/SECTOR
HVAC & Climate Tech
HQ
Houston, Texas
WEBSITE
Helix Earth develops the first retrofit system that gives commercial buildings fresher air, lower humidity, and lower energy costs without replacing a thing. Powered by NASA technology.
LiftOFF Technology
FOUNDER
INDUSTRY/SECTOR
Energy Storage & Batteries
HQ
Somerville/Boston, Massachusetts
WEBSITE
LiftOFF Technology develops next-generation battery cells that deliver up to 3× higher energy density with improved safety, using abundant, domestically available materials. Their drop-in technology scales on existing lithium-ion manufacturing infrastructure. Backed by Breakthrough Energy and the U.S. Department of Energy’s Genesis Mission, they accelerate technology development through AI-driven R&D.
MacroCycle Technologies
FOUNDER
INDUSTRY/SECTOR
Sustainability & Circular Materials
HQ
Cambridge, Massachusetts
WEBSITE
MacroCycle Technologies’ patented technology recycles plastic and polyester waste into virgin-grade MacroCycle PET or polyester resins to improve companies’ ability to meet sustainability goals, including satisfaction of PCR Regulations, elimination of landfill and ocean-bound plastics, and lowered Scope 3 emissions, all without a green premium.
Oleo
FOUNDER
INDUSTRY/SECTOR
Biofuels & Biomanufacturing
HQ
Berkeley, California
WEBSITE
Oleo delivers reliable, lower-carbon fuel feedstocks at price parity with conventional alternatives. By converting waste into economical feedstocks, Oleo unlocks new production capacity for profitable advanced fuel pathways, ultimately, accelerating the transition to cleaner fuels.
Pascal
FOUNDER
INDUSTRY/SECTOR
HVAC & Sustainable Cooling
HQ
Cambridge, Massachusetts
Pascal is commercializing solid refrigerants as cleaner, more efficient alternatives to gas refrigerants in a wide variety of heating, cooling, and refrigeration systems. Solid refrigerants eliminate the greenhouse gas emissions and air and water pollution caused by leaking gas refrigerants while improving the energy efficiency of refrigeration systems by at least 20%, all at similar costs to conventional systems. Pascal has fully integrated its solid refrigerant into a commercial refrigerator and is actively developing a solid refrigerant beverage cooler, in partnership with a major beverage brand.
Phase3D
FOUNDER
INDUSTRY/SECTOR
Additive Manufacturing & Inspection
HQ
Chicago, Illinois
WEBSITE
Phase3D is on a mission to empower the additive manufacturing industry by offering a trusted part quality assurance technology. We produce quantitative measurements of the AM process using Fringe Projection to correlate build anomalies to material properties and part quality for all AM applications.
Sensate Robotics
FOUNDER
INDUSTRY/SECTOR
Robotics & Tactile Sensing
HQ
Los Angeles, California
WEBSITE
Sensate Roboticsâ„¢ builds multimodal tactile sensors and robotic gripping systems that give machines a true sense of touch and automate the work where irregular objects, quality judgment, and delicate handling meet a hard labor constraint. The company’s debut is in fruit handling, where the need is urgent, and the work still depends on human hands. The same technology reaches every industry where touch is the missing input.
SirenOpt
FOUNDER
INDUSTRY/SECTOR
Advanced Manufacturing & Materials Characterization
HQ
San Leandro, California
WEBSITE
SirenOpt provides real-time, non-destructive materials characterization for advanced manufacturing using cold atmospheric plasma and AI through its PlasmaSens platform, targeting batteries, semiconductors, aerospace, power generation and other thin-film/coating manufacturers.
VioNano Innovations
FOUNDER
INDUSTRY/SECTOR
Semiconductor Materials
HQ
Cambridge, Massachusetts
WEBSITE
VioNano develops specialty polymeric materials for advanced semiconductor manufacturing, helping chipmakers build smaller, faster, and more cost-effective chips for AI and quantum infrastructure.
Japan-Based Startups
AirMembrane
INDUSTRY/SECTOR
Graphene / 2D Materials
HQ
Tsukuba, Ibaraki, Japan
WEBSITE
AirMembrane, a 2017 AIST spinout, grows large-area graphene and moves it intact onto the substrate an application needs, or onto no substrate at all. Our plasma CVD growth and mechanical transfer run at speeds that conventional wet transfer cannot reach. TEM and cryo-EM grids and graphene FET sensor chips ship today; EUV pellicles are in development under a NEDO program. We are looking for partners who need an ultrathin, low-Z window or support film.
bitBiome
FOUNDER
INDUSTRY/SECTOR
Biotech / Biomanufacturing
HQ
Shinjuku-ku, Tokyo, Japan
WEBSITE
bitBiome is a next-generation AI x Bio platform company driving innovation in biomanufacturing. By combining proprietary single-cell genome sequencing with the world’s largest microbial gene database (over 3 billion genes) and AI-driven predictive modeling, bitBiome unlocks biological functions at scale. Partnering across pharmaceuticals, fine chemicals, materials, and environmental applications, the company provides end-to-end solutions—from target discovery to process development—for a sustainable bioeconomy.
miibio
INDUSTRY/SECTOR
Biochemicals / Semiconductor / Biomanufacturing / Synthetic Biology / Climate Tech
HQ
Tokyo, Japan
WEBSITE
From Grain Fields to Silicon Fab. By using biomass as a raw material—without relying on petroleum at all—and utilizing a production process that combines microbial fermentation with proprietary light control, miibio achieves low-cost production of biochemicals. We focus on the production of semiconductor-related materials—substances of critical importance, particularly in the context of economic security—as well as high-value-added performance chemicals such as super-engineering plastics. By producing products with a price advantage over conventional petroleum-derived alternatives, we provide the world with a solution that simultaneously achieves petroleum independence and economic security (supply chain resilience).
Nano Chemix
FOUNDER
INDUSTRY/SECTOR
Advanced Materials / Nanotechnology / Optics
HQ
Tsukuba, Ibaraki, Japan
WEBSITE
Nano Chemix is a Tsukuba-based deep-tech startup developing high-performance metal oxide nanoparticles that can be transparently dispersed in organic materials. Using precision synthesis and surface design technologies, the company enables transparent composite materials compatible with solvents and resins, supporting optics applications such as lenses, glasses-type devices, and photonic integrated circuits.
OptQC
INDUSTRY/SECTOR
Optical Quantum Computing
HQ
Toshima-ku, Tokyo, Japan
WEBSITE
OptQC is a deep-tech startup aiming to provide a next-generation computing platform using optical quantum technology. Built upon over 25 years of research at the Furusawa Laboratory of the University of Tokyo, OptQC accelerates the practical application of quantum technology in the global market through an approach that simultaneously promotes research, development, and business.
Rhinoflux
FOUNDER
INDUSTRY/SECTOR
Renewable Energy / CDR
HQ
Kyoto, Japan
WEBSITE
Rhinoflux is an energy company spun out of Kyoto University. Using a combustion-free, aqueous chemical reaction, it efficiently generates electricity from vast biomass resources and captures pure CO₂ as a co-product. Deployed on-site rather than at central power stations, Rhinoflux brings unburned power generation to the real world — low-cost electricity and sellable CO₂ from biomass.
Rumi Light
FOUNDER
INDUSTRY/SECTOR
Product Dev / High-Speed Interconnect
HQ
Fukuoka, Japan
WEBSITE
Rumi Light develops DataFlux, a PCB-free interconnect platform for AI infrastructure. Its proprietary composite-material architecture enables faster data movement with lower power, lower system cost, and drop-in integration beyond conventional PCB limitations. Engineering samples are completed, with customer evaluations underway in Japan, Taiwan, and the United States.
XELA Robotics
FOUNDER
INDUSTRY/SECTOR
Robotics / Tactile Sensing / Industrial Automation
HQ
Tokyo, Japan
WEBSITE
XELA Robotics is a Tokyo-based robotics startup spun out from Waseda University. It develops tactile sensing systems, including uSkin sensors and uAi software, that help robots feel contact, improving how they grasp, manipulate, and interact with real environments. The company focuses on making automation more reliable, adaptable, and accessible across manufacturing, logistics and humanoids.





















